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CIRCADIAN LOCOMOTOR OUTPUT CYCLES KAPUT PROTEINS
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DeCS
Descriptor
English
:
CLOCK Proteins
Descriptor
Spanish
:
Proteínas CLOCK
Descriptor
Portuguese
:
Proteínas CLOCK
Synonyms
English
:
CLOCK Protein
Circadian Locomotor Output Cycles Kaput Proteins
Tree Number:
D08.811.913.050.134.415.500.049
D12.644.128.100
D12.776.189.200
D12.776.260.103.562
D12.776.930.125.562
Definition
English
:
Basic helix-loop-helix (bHLH) domain-containing
proteins
that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in
CIRCADIAN RHYTHM
regulation.
Clock proteins
combine with Arntl
proteins
to form heterodimeric
transcription factors
that are specific for
E-BOX ELEMENTS
and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This
transcriptional activation
also sets into
motion
a time-dependent
feedback
loop which in turn down-regulates the expression of
clock proteins.
History Note
English
:
2010(1997)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
53609
Unique Identifier:
D056926
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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